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Recombinant Human Reticulocalbin 3/RCN3 Protein (aa 21-328, His Tag)
SKU: PKSH033292-50
Recombinant Human Reticulocalbin 3/RCN3 Protein (aa 21-328, His Tag)
| SKU # | PKSH033292 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | EF-Hand Calcium-Binding Protein RLP49, RCN3, Reticulocalbin-3 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Lys21-Leu328 |
| Accession | Q96D15 |
| Calculated Molecular Weight | 36.2 kDa |
| Observed Molecular Weight | 43 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, 10% Glycerol, pH 7.4. |
| Reconstitution | Not Applicable |
Background
Reticulocalbin-3 is a member of the CREC family that is involved in the secretory pathway. Members of the CREC family consist of a number of multiple EF-hand domains. Reticulocalbin-3 localizes to the endoplasmic reticulum lumen. The bioinformaticanalysis of Reticulocalbin-3 reveal that it is a putative Ca2+-binding protein. In addition; it has been shown that autoactivation and secretion of PACE4 was increased upon co-expression with Reticulocalbin-3. The proPACE4-RCN-3 complex is plays an important role in the biosynthesis of PACE4.