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Recombinant Human ROR1 Protein (His Tag)
SKU: PKSH033647-50
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Recombinant Human ROR1 Protein (His Tag)
| SKU # | PKSH033647 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Inactive tyrosine-protein kinase transmembrane receptor ROR1, NTRKR1, Neurotrophic tyrosine kinase, ROR1, receptor-related 1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gln30-Glu403 |
| Accession | Q01973 |
| Calculated Molecular Weight | 42.8 kDa |
| Observed Molecular Weight | 60-80 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Receptor tyrosine kinase-like orphan receptor 1 (ROR1); also known as neurotrophic tyrosine kinase; it is a member of the ROR family within receptor tyrosine kinases (RTK) superfamily. Human ROR1 is a type I transmembrane protein with 937 amino acids (aa) in length. It contains a 29 aa signal sequence; a 377 aa extracellular domain (ECD); a 21 aa transmembrane segment; and a 510 aa cytoplasmic region. ROR1 expressed strongly in human heart; lung and kidney; but weakly in the CNS. At developmental stage; it expressed at high levels during early embryonic development. ROR1 has been shown to have very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. It may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.