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Recombinant Human Semaphorin-4D/CD100 Protein (His tag)
SKU: PDMH100057-100
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Recombinant Human Semaphorin-4D/CD100 Protein (His tag)
| SKU # | PDMH100057 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | A8, BB18, COLL4, Collapsin 4, GR3, MSEMA, SEMA J, SEMA4D, Sema H, SemaH, Semacl2, Semcl 2 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met1-Arg734 |
| Accession | Q92854 |
| Calculated Molecular Weight | 80.6 kDa |
| Observed Molecular Weight | 90 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Semaphorin-4D is also known as A8;BB18; GR3; CD100. Semaphorin-4D belongs to the semaphorin family containing 1 Ig-like C2-type domain; 1 PSI domain and 1 Sema domain. It is the cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. It promotes the migration of cerebellar granule cells and of endothelial cells; regulates dendrite and axon branching and morphogenesis. Semaphorin-4D Plays a role in the immune system; Promotes signaling via SRC and PTK2B/PYK2; which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade.