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Recombinant Human SENP8 Protein (His Tag)
SKU: PKSH033028-50
Recombinant Human SENP8 Protein (His Tag)
| SKU # | PKSH033028 |
| Expression Host | E.coli |
Description
| Synonyms | DEN1, Deneddylase-1, NEDD8-Specific Protease 1, NEDP1, PRSC2, Protease Cysteine 2, SENP8, Sentrin-Specific Protease 8, Sentrin/SUMO-Specific Protease SENP8 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Lys212 |
| Accession | Q96LD8 |
| Calculated Molecular Weight | 26.2 kDa |
| Observed Molecular Weight | 22 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| Reconstitution | Not Applicable |
Background
Sentrin-Specific Protease 8 (SENP8) mediates the reversible covalent modification of proteins by NEDD8. SENP8 catalyzes the full-length NEDD8 to generate its mature form and deconjugation of NEDD8 from targeted proteins such as CUL2 , CUL4A in vivo, or p53. but it does not show activity against ubiquitin or SUMO proteins.