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Recombinant Human SerpinA3/AACT Protein (His Tag)
SKU: PKSH033032-50
Recombinant Human SerpinA3/AACT Protein (His Tag)
| SKU # | PKSH033032 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | AACT, ACT, Alpha-1-Antichymotrypsin, Cell Growth-Inhibiting Gene 24/25 Protein, GIG24, GIG25, MGC88254, SERPINA3, Serpin A3 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | His24-Ala423(Lys267Arg) |
| Accession | P01011 |
| Calculated Molecular Weight | 46.3 kDa |
| Observed Molecular Weight | 50-80 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, pH 7.5. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Serpin A3 belongs to the Serpin superfamily of serine protease inhibitors. Serpin A3 has been shown to inhibit some serine proteases, such as neutrophil cathepsin G and mast cell chymase. Serpin A3 is synthesized initially in the liver and secreted in plasma. Serpin A3 has been found in the amyloid plaques from the hippocampus of Alzheimer disease brains. In addition to, Serpin A3 is associated with liver disease and Parkinson disease and chronic obstructive pulmonary disease.