Total Price: $0.00
Contact Information
Recombinant Human SERPINB1/PI2 Protein (Baculovirus, His Tag)
SKU: PKSH030808-50
Recombinant Human SERPINB1/PI2 Protein (Baculovirus, His Tag)
| SKU # | PKSH030808 |
| Expression Host | Baculovirus-Insect Cells |
Description
| Synonyms | EI, ELANH2, HEL-S-27, HEL57, LEI, Leukocyte elastase inhibitor, M/NEI, MNEI, Monocyte/neutrophil elastase inhibitor, PI-2, PI2, Peptidase inhibitor 2, SERPINB1 |
| Species | Human |
| Expression Host | Baculovirus-Insect Cells |
| Sequence | Met 1-Pro 379 |
| Accession | P30740 |
| Calculated Molecular Weight | 44.0 kDa |
| Observed Molecular Weight | 44 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0, 10% glycerol Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
SerpinB1 is an endogenous inhibitor of serine proteases recognized for its anti-inflammatory and host-protective properties. Serum SerpinB1 levels are elevated in patients with type 2 diabetes compared with that in healthy subjects and are negatively correlated with serum LDL-C. serpinB1 as an endogenous protein that can potentially be harnessed to enhance functional beta cell mass in patients with diabetes.