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Recombinant Human SMPDL3A Protein (His Tag)
SKU: PKSH033291-50
Recombinant Human SMPDL3A Protein (His Tag)
| SKU # | PKSH033291 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | ASM-Like Phosphodiesterase 3a, ASML3A, Acid Sphingomyelinase-Like Phosphodiesterase 3a, SMPDL3A |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Leu23-Tyr453 |
| Accession | Q92484 |
| Calculated Molecular Weight | 49.9 kDa |
| Observed Molecular Weight | 59 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Acid sphingomyelinase-like phosphodiesterase 3a (SMPDL3A ) is a novel liver X receptor (LXR) -regulated gene; with an LXR response element within its promoter. The induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. LXR function as physiological sensors of cholesterol metabolites (oxysterols); regulating key genes involved in cholesterol and lipid metabolism. LXRs have been extensively studied in both human and rodent cell systems; revealing their potential therapeutic value in the contexts of atherosclerosis and inflammatory diseases.