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Recombinant Human SORD Protein (His Tag)
SKU: PKSH033074-50
Recombinant Human SORD Protein (His Tag)
| SKU # | PKSH033074 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | L-Iditol 2-Dehydrogenase, SORD, Sorbitol Dehydrogenase |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ala2-Pro357 |
| Accession | AAH21085.1 |
| Calculated Molecular Weight | 39.3 kDa |
| Observed Molecular Weight | 43 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, 5mM DTT, 20% Glycerol, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Sorbitol dehydrogenase, also known as L-iditol 2-dehydrogenase and SORD, is a member of the zinc-containing alcohol dehydrogenase family. SORD exsits in a homotetramer and binds one zinc ion per subunit. SORD is expressed in kidney and epithelial cells of both benign and malignant prostate tissue. SORD can converts sorbitol to fructose and catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase to make up the sorbitol pathway. SORD is up-regulated by androgens and down-regulated by castration. SORD may play a role in the sperm motility by providing an energetic source for sperm.