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Recombinant Human TGFBR2 Protein (Fc Tag)
SKU: PKSH033426-50
Recombinant Human TGFBR2 Protein (Fc Tag)
| SKU # | PKSH033426 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGF-beta receptor type-2, TGF-beta type II receptor, TGFBR2, TGFR-2, TGFbeta-RII, Transforming growth factor-beta receptor type II |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Thr 23-Asp159 |
| Accession | P37173 |
| Calculated Molecular Weight | 42.6 kDa |
| Observed Molecular Weight | 59 kDa |
| Tag | C-Fc |
| Bio-activity | Measured by its ability to inhibit TGF-beta 1 activity on TF‑1 human erythroleukemic cells. The ED50 for this effect is 18.41 ng/ml in the presence of 100pg/ml of recombinant human TGF-beta 1. |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
TGFBR2 is a single-pass type I membrane protein and contains one protein kinase domain. TGFBR2 exsits as a heterodimeric complex with another receptor protein and binds TGF-beta. Signals triggered through the TGF-beta receptor complex prompt various responses by the cell. One such response is to inhibit cell growth and division. Based on this action, the TGF-beta receptor type 2 is sometimes called a tumor suppressor. Defects in TGFBR2 have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler-Weber-Rendu syndrome and the development of various types of tumors.