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Recombinant Human TIMP-4/TIMP4 Protein (His Tag)
SKU: PKSH033119-50
Recombinant Human TIMP-4/TIMP4 Protein (His Tag)
| SKU # | PKSH033119 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Metalloproteinase inhibitor 4, TIMP-4, TIMP4, Tissue inhibitor of metalloproteinases 4 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Cys30-Pro224 |
| Accession | Q99727 |
| Calculated Molecular Weight | 23.5 kDa |
| Observed Molecular Weight | 24 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene, belongs to the protease inhibitor I35 (TIMP) family. The protein complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.