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Recombinant Human TL1A Protein (Fc Tag)
SKU: PKSH030438-100
Recombinant Human TL1A Protein (Fc Tag)
| SKU # | PKSH030438 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | TL1, TL1A, TNF Ligand-Related Molecule 1, TNFSF15, Tumor Necrosis Factor Ligand Superfamily Member 15, VEGI, Vascular Endothelial Cell Growth Inhibitor |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Leu72-Leu251 |
| Accession | NP_005109.2 |
| Calculated Molecular Weight | 48.9 kDa |
| Tag | N-hFc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. TL1A is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It mediates activation of NF-kappa-B. It also inhibits vascular endothelial growth and angiogenesis (in vitro). TL1A promotes activation of caspases and apoptosis. It is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor.