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Recombinant Human TNFSF4/OX40L Protein (Fc Tag)
SKU: PKSH030721-100
Recombinant Human TNFSF4/OX40L Protein (Fc Tag)
| SKU # | PKSH030721 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD134L, CD252, GP34, Glycoprotein Gp34, OX-40, OX40 ligand, OX40L, TAX transcriptionally-activated glycoprotein 1, TNFSF4, TXGP1, Tumor necrosis factor ligand superfamily member 4 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gln51-Leu183 |
| Accession | NP_003317.1 |
| Calculated Molecular Weight | 42.1 kDa |
| Tag | N-mFc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX4. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.