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Recombinant Human TNFSF4/OX40L Protein (His Tag)(Active)
SKU: PKSH032842-50
Recombinant Human TNFSF4/OX40L Protein (His Tag)(Active)
| SKU # | PKSH032842 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD134L, CD252, GP34, Glycoprotein Gp34, OX-40, OX40 ligand, OX40L, TAX transcriptionally-activated glycoprotein 1, TNFSF4, TXGP1, Tumor necrosis factor ligand superfamily member 4 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gln51-Leu183 |
| Accession | P23510 |
| Calculated Molecular Weight | 16.3 kDa |
| Observed Molecular Weight | 20-30 kDa |
| Tag | N-His |
| Bio-activity | Loaded Biotinylated Human OX40L-His on AR2G Biosensor, can bind Human OX40-Fc with an affinity constant of 70.3 nM as determined in BLI assay. |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein.OX40L is expressed on the surface of activated B cells; T cells; dendritic cells and endothelial cells. OX40L binds to OX40 (CD134); a member of the TNF receptor superfamily that is expressed predominantly on activated CD4+ T cells. OX40-OX40L co-stimulates signal to promote the survival and proliferation of activated CD4+ T cells and prolong the immune response. It involved in T-cell proliferation and cytokine production. Additional; it has been found association with systemic lupus erythematosus; no association with occurrence of atherosclerosis.