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Recombinant Human TRAIL R3/TNFRSF10C Protein (Fc & His Tag)
SKU: PKSH033129-50
Recombinant Human TRAIL R3/TNFRSF10C Protein (Fc & His Tag)
| SKU # | PKSH033129 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Antagonist Decoy Receptor for TRAIL/Apo-2L, DcR1, Decoy Receptor 1, Decoy TRAIL Receptor Without Death Domain, Lymphocyte Inhibitor of TRAIL, TNF-Related Apoptosis-Inducing Ligand Receptor 3, TRAIL Receptor , Tumor Necrosis Factor Receptor Superfamily Member 10C |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ala26-Ala221 |
| Accession | O14798 |
| Calculated Molecular Weight | 48.7 kDa |
| Observed Molecular Weight | 90 kDa |
| Tag | C-Fc-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Tumor Necrosis Factor Receptor Superfamily Member 10C (TNFRSF10C) is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. TNFRSF10C has the TRAIL-binding extracellular cysteine-rich domains; lacks the intracellular signaling domain. As a result; binding of TRAIL to TRAIL R3 doesn’t transduce an apoptosis signal. The expression of TRAIL R3 gene has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.