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Recombinant Human TREML2/TLT2 Protein (Fc Tag)
SKU: PKSH033146-50
Recombinant Human TREML2/TLT2 Protein (Fc Tag)
| SKU # | PKSH033146 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | C6orf76, TLT2, Trem-like transcript 2 protein, Triggering receptor expressed on myeloid cells-like protein 2 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gly19-Ser268 |
| Accession | AAI25079.1 |
| Calculated Molecular Weight | 54.2 kDa |
| Observed Molecular Weight | 80-110 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Trem-like transcript 2 protein (TLT2), also known as Triggering receptor expressed on myeloid cells-like protein 2, TLT2 and C6orf76, is single-pass type I membrane protein. TREML2 contains one Ig-like V-type domain, which can be induced in CD4 T-cell by concanavalin-A. As a cell surface receptor, TREML2 may play a role in the innate and adaptive immune response. TREML2 also acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. It has shown that TREML2 may be involved in the innate immune response based on its expression profile and the fact that it is up-regulated in response to inflammation.