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Recombinant Human TrkB/NTRK2 Protein (His Tag)(Active)
SKU: PKSH033579-50
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Recombinant Human TrkB/NTRK2 Protein (His Tag)(Active)
| SKU # | PKSH033579 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | BDNF/NT-3 Growth Factors Receptor, GP145-TrkB, NTRK2, Neurotrophic Tyrosine Kinase Receptor Type 2, TRKB, Trk-B, TrkB Tyrosine Kinase, Tropomyosin-Related Kinase B |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Cys32-His430 |
| Accession | Q16620 |
| Calculated Molecular Weight | 45.3 kDa |
| Observed Molecular Weight | 60-105 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
The TRK Family of Tyrosine Kinase Receptor consists of 3 members: TrkA, TrkB and TrkC. The three TRK family proteins have different ligand specificities. They connect to different neurotrophins, including NGF, BDNF, NT-3NT-4/5. TRKA binds NGF, TRKB binds BDNF and NT-3, TRKC binds NT-4/5. At the protein sequence level, human and rat TRKB have greater than 90% sequence identity and the proteins exbihit cross-species activity. TRKB is primarily expressed in the nervous system and it also expression in a wide variety of tissues with low levels.