Total Price: $0.00
Contact Information
Recombinant Human Tropomyosin α-3 Chain/TPM3 Protein
SKU: PKSH033151-50
Recombinant Human Tropomyosin α-3 Chain/TPM3 Protein
| SKU # | PKSH033151 |
| Expression Host | E.coli |
Description
| Synonyms | Gamma-Tropomyosin, TPM3, Tropomyosin Alpha-3 Chain, Tropomyosin-3, Tropomyosin-5, hTM5 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Met248 |
| Accession | P06753-2 |
| Calculated Molecular Weight | 29.0 kDa |
| Observed Molecular Weight | 32 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Tropomyosin Alpha-3 Chain (TPM3) is a member of the Tropomyosin family. TPM3 exists as a heterodimer consisting of an alpha and a beta chain. TPM3 plays a central role in association with the Troponin complex and in the calcium dependent regulation of vertebrate striated muscle contraction. Defects in TPM3 are the cause of thyroid papillary carcinoma. Mutations in the TPM3 gene cause autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are linked with cancer.