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Recombinant Human TXNRD1/TRXR1 Protein (aa 161-647, His Tag)
SKU: PKSH030732-100
Recombinant Human TXNRD1/TRXR1 Protein (aa 161-647, His Tag)
| SKU # | PKSH030732 |
| Expression Host | E.coli |
Description
| Synonyms | GRIM-12, TR, TR1, TRXR1, TXNR |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Tyr 161-Cys 647 |
| Accession | Q16881-1 |
| Calculated Molecular Weight | 55.0 kDa |
| Observed Molecular Weight | 60 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidative damage. We investigated the association between TXNRD1 polymorphisms and ATDH susceptibility. Moreover, TXNRD1 is an essential selenium-containing enzyme involved in detoxification of reactive oxygen species (ROS) and redox signaling. And genetic variations in TXNRD1 favor the development of Drug-induced liver injury (DILI), which is the most common adverse drug reaction.