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Recombinant Human UBE2B/HR6B Protein (His Tag)
SKU: PKSH033180-50
Recombinant Human UBE2B/HR6B Protein (His Tag)
| SKU # | PKSH033180 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | HR6B, RAD6 Homolog B, RAD6B, UBE2B, Ubiquitin Carrier Protein B, Ubiquitin-Conjugating Enzyme E2 B, Ubiquitin-Conjugating Enzyme E2-17 kDa, Ubiquitin-Protein Ligase B, hHR6B |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Ser152 |
| Accession | P63146 |
| Calculated Molecular Weight | 18.3 kDa |
| Observed Molecular Weight | 17 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| Reconstitution | Not Applicable |
Background
Ubiquitin-Conjugating Enzyme E2 B (UBE2B) is a member of the ubiquitin-conjugating enzyme family. UBE2B accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. It is shown that UBE2B interacts with RAD18; UBR2; and WAC. UBE2B is required for post-replicative DNA damage repair. Additional; UBE2B plays a role in sepsis-induced muscle protein proteolysis and cancer-induced cachexia.