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Recombinant Human UBE2V2/DDVIT1 Protein (His Tag)
SKU: PKSH033191-50
Recombinant Human UBE2V2/DDVIT1 Protein (His Tag)
| SKU # | PKSH033191 |
| Expression Host | E.coli |
Description
| Synonyms | DDVit 1, EDAF-1, EDPF-1, Enterocyte Differentiation-Associated Factor 1, Enterocyte Differentiation-Promoting Factor 1, MMS2, MMS2 Homolog, UBE2V2, UEV2, Ubiquitin-Conjugating Enzyme E2 Variant 2, Vitamin D3-Inducible Protein |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Asn145 |
| Accession | Q15819 |
| Calculated Molecular Weight | 18.5 kDa |
| Observed Molecular Weight | 18 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 50mm HEPES,150mM NaCl, pH 7.0. |
| Reconstitution | Not Applicable |
Background
Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2) is an enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2V2 can be detected in the placenta, colon, liver, and skin. It forms a heterodimer with UBE2N. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains and which leads to protein degradation by the proteasome. UBE2V2 mediates transcriptional activation of target genes. It plays a role in the control of progress through the cell cycle and differentiation. It also plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.