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Recombinant Human UCHL1 protein (GST tag)
SKU: PDEH100126-100
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Recombinant Human UCHL1 protein (GST tag)
| SKU # | PDEH100126 |
| Expression Host | E. coli |
Description
| Synonyms | Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1;UCH-L1;Neuron Cytoplasmic Protein 9.5;PGP 9.5;PGP9.5;Ubiquitin Thioesterase L1;UCHL1;HEL-117;NDGOA;PARK5;Uch-L1 |
| Species | Human |
| Expression_host | E.coli |
| Sequence | Met1-Cys220 |
| Accession | P09936 |
| Mol_Mass | 49.1 kDa |
| AP_Mol_Mass | 30 kDa |
| Tag | N-GST |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin level | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 (UCHL1) belongs to the Peptidase C12 family. UCHL1 is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. UCHL1 is a component of the ubiquitin system, which has a fundamental role in regulating various biological activities. UCHL1 is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer of UCHL1 may have ATP-independent ubiquitin ligase activity.