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Recombinant Human ULBP2/N2DL-2 Protein (Fc Tag)
SKU: PKSH030893-100
Recombinant Human ULBP2/N2DL-2 Protein (Fc Tag)
| SKU # | PKSH030893 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | ALCAN-Alpha, N2DL-2, N2DL2, NKG2D Ligand 2, NKG2DL2, RAET1H, Retinoic Acid Early Transcript 1H, UL16-Binding Protein 2, ULBP2 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Ser 217 |
| Accession | Q9BZM5 |
| Calculated Molecular Weight | 48.7 kDa |
| Observed Molecular Weight | 58 kDa |
| Tag | C-hFc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
NKG2D ligand 2; also known as N2DL-2; NKG2DL2; ALCAN-alpha; Retinoic acid early transcript 1H; UL16-binding protein 2; ULBP2 and N2DL2; is cell membrane protein which belongs to theMHC class I family. ULBP2 / N2DL-2 is expressed in various types of cancer cell lines and in the fetus; but not in normal tissues. ULBP2 / N2DL-2 is a ligand for the NKG2D receptor; together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells; resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2; STAT5; ERK and PI3K kinase/Akt signal transduction pathway.