Total Price: $0.00
Contact Information
Recombinant Human Uroplakin-2/UPK2 Protein (His Tag)
SKU: PKSH033198-50
Recombinant Human Uroplakin-2/UPK2 Protein (His Tag)
| SKU # | PKSH033198 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | UP2, UPII, UPK2, Uroplakin II, Uroplakin-2 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Asp26-Gly155 |
| Accession | O00526 |
| Calculated Molecular Weight | 14.8 kDa |
| Observed Molecular Weight | 27 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Uroplakin-2 is a single-pass type I membrane protein that belongs to the uroplakin-2 family. Uroplakin-2 is a component of the asymmetric unit membrane (AUM) and expressed in the ureter, a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. Uroplakin-2 forms heterodimer with UPK1A that is necessary for exiting out of the endoplasmic reticulum (ER). Uroplakin-2 may play an important role in regulating the assembly of the AUM. AUM is believed to strengthen the urothelium by preventing cell rupture during bladder distention.