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Recombinant Human UROS/UROIIIS Protein (His Tag)
SKU: PKSH033200-50
Recombinant Human UROS/UROIIIS Protein (His Tag)
| SKU # | PKSH033200 |
| Expression Host | E.coli |
Description
| Synonyms | Hydroxymethylbilane Hydrolyase [Cyclizing], UROIIIS, UROS, Uroporphyrinogen-III Cosynthase, Uroporphyrinogen-III Synthase |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Cys265 |
| Accession | P10746 |
| Calculated Molecular Weight | 29.7 kDa |
| Observed Molecular Weight | 29 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 10% Glycerol, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Uroporphyrinogen-III Synthase is an enzyme which belongs to the uroporphyrinogen-III synthase family. Uroporphyrinogen-III Synthase is ubiquitous and it is involved in Porphyrin metabolism. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as Methionine synthesis (Vitamin B12) or oxygen transport (Heme). Uroporphyrinogen-III Synthase can catalyze cyclization of the linear Tetrapyrrole, Hydroxymethylbilane, to the Macrocyclic Uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of Porphyrins. Defects in Uroporphyrinogen-III Synthase are the cause of Congenital Erythropoietic Porphyria (CEP).