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Recombinant Human Vaspin/SerpinA12 Protein (GST Tag)
SKU: PKSH033534-50
Recombinant Human Vaspin/SerpinA12 Protein (GST Tag)
| SKU # | PKSH033534 |
| Expression Host | E.coli |
Description
| Synonyms | OL-64, SERPINA12, Serpin A12, Vaspin, Visceral Adipose Tissue-Derived Serine Protease Inhibitor, Visceral Adipose-Specific Serpin |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Leu21-Lys414 |
| Accession | Q8IW75 |
| Calculated Molecular Weight | 71.4 kDa |
| Observed Molecular Weight | 72 kDa |
| Tag | N-GST |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 80 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl, 160mM NaCl, 0.2mM PMSF, 1mM DTT, 10% Glycerine, pH 7.2 . |
| Reconstitution | Not Applicable |
Background
Vaspin (Visceral Adipose-Specific SERPIN) is a newly described adipokine. Vaspin has three β-sheets; nine α-helices; and one central loop; the structure is part of the set of distinctive features that are descriptive of Serpin family members. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that Vaspin mRNA expression in visceral fat is positively correlated with BMI and percent of body fat. and could be associated with parameters of obesity; insulin resistance; and glucose metabolism. These findings suggest a potential clinical use for Vaspin in ameliorating certain aberrations seen in the obesity metabolic syndrome.