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Recombinant Mouse ABL1/c-Abl Protein (His tag)
SKU: PDEM100082-100
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Recombinant Mouse ABL1/c-Abl Protein (His tag)
| SKU # | PDEM100082 |
| Expression Host | E. coli |
Description
| Synonyms | Abelson tyrosine protein kinase 1;ABL 1;bcr/abl;JTK7;p150;Proto-oncogene c-Abl;v abl |
| Species | Mouse |
| Expression_host | E.coli |
| Sequence | Met 1-Asn 193 |
| Accession | P00520 |
| Mol_Mass | 21.1 kDa |
| AP_Mol_Mass | 25 kDa |
| Tag | N-His |
| Bio_Activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin level | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.