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Recombinant Mouse MME/CD10/Neprilysin protein (His tag)– MSE Supplies LLC

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Recombinant Mouse MME/CD10/Neprilysin protein (His tag)

Recombinant Mouse MME/CD10/Neprilysin protein (His tag)

SKU: PDEM100075-100

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Recombinant Mouse MME/CD10/Neprilysin protein (His tag)

 

SKU # PDEM100075
Expression Host E. coli

 

Description    

Synonyms Atriopeptidase;CALLA;Enkephalinase;EPN;NEP;Neprilysin;neprilysin-390;neprilysin-411;SFE;Skin fibroblast elastase
Species Mouse
Expression_host E.coli
Sequence Met 461-Trp 750
Accession Q61391
Mol_Mass 31.8 kDa
AP_Mol_Mass 32 kDa
Tag N-His
Bio_Activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level Please contact us for more information.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis


Background

CD10, also known as neprilysin, common acute lymphoblastic leukemia antigen (CALLA), or neutral endopeptidase (NEP), is a zinc-dependent transmembrane metallo-endopeptidase. CD10 cleaves peptides at the N-terminal side of hydrophobic amino acid residues and deactivates a variety of signaling peptides. CD10 was shown to be one of the markers for a natural killer cell-restricted progenitor in fetal and adult tissues. Studies also suggest CD10 as a phenotypic marker to distinguish mature neutrophils from immature neutrophils in patients with inflammation. In addition, CD10+GPR77+ carcinoma-associated fibroblasts (CAFs) promote tumor formation and chemoresistance.