Total Price: $0.00
Contact Information
Recombinant Rat Ngf Protein (His tag)
SKU: PDER100054-100
To better serve you, we would like to discuss your specific requirement.
Please Contact Us for a quote.
Recombinant Rat Ngf Protein (His tag)
| SKU # | PDER100054 |
| Expression Host | E. coli |
Description
| Synonyms | Beta nerve growth factor precursor, HSAN5, MGC161426, NGFB, NGFBMGC161428, beta subunit, beta-NGF, beta-nerve growth factor, betaNGF, nerve growth factor, nerve growth factor (beta polypeptide) |
| Species | Rat |
| Expression Host | E.coli |
| Sequence | Ser 122-Gly 241 |
| Accession | P25427 |
| Calculated Molecular Weight | 13.1 kDa |
| Observed Molecular Weight | 15 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Nerve growth factor (NGF) is important for the development and maintenance of the sympathetic and sensory nervous systems. NGF protein was identified as a large complex consisting of three non-covalently linked subunits, α, β, and γ, among which, the β subunit, called β-NGF (beta-NGF), was demonstrated to exhibits the growth-stimulating activity of NGF protein. NGFB/beta-NGF gene is a member of the NGF-beta family and encodes a secreted protein that homodimerizes and is incorporated into a larger complex. NGF protein acts via at least two receptors on the surface of cells (TrkA and p75 receptors) to regulate neuronal survival, promote neurite outgrowth, and up-regulate certain neuronal functions such as mediation of pain and inflammation. Also, previous studies indicated that NGF may also have an important role in the regulation of the immune system.