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Recombinant Vaccinia Virus B18R / B19R Protein (His Tag)– MSE Supplies LLC

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Recombinant ZIKV (strain Zika SPH2016) Stem/anchor domain of flavivirus envelope glycoprotein E protein (Fc Tag)

Recombinant Vaccinia Virus B18R / B19R Protein (His Tag)

SKU: PKSV030257-100

  • £62300
  • Save £7000

Recombinant Vaccinia Virus B18R / B19R Protein (His Tag)

 

SKU # PKSV030257
Expression Host Baculovirus-Insect Cells

 

Description

Synonyms Vaccinia Virus B18R;B19R
Species Vaccinia Virus
Expression_host Baculovirus-Insect Cells
Sequence Met1-Glu351
Accession P25213
Mol_Mass 39.8 kDa
AP_Mol_Mass 46 kDa
Tag C-His
Bio_Activity Not validated for activity

 

Properties

Purity > 90 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.

Background

B18R is a type I interferon (IFN)-binding protein, which is encoded by the B18R open reading frame in the WR (WesternReserve)strain of vaccinia virus. Itis alsoknownasB19RintheCopenhagenstrainofVaccinia. B18R exists in a soluble and a membrane-bound form. As a type I IFN receptor, B18R has a broad species specificity. It has high affinity for human IFN-alpha and also binds rabbit, bovine, rat, pig, and mouse IFN-alpha and IFN-beta. It has been shown that secreted B18R binds to uninfected and infected cells. It presents at the cell surface and protects cells from the antiviral state induced by IFN-alpha and IFN-beta. Binding of soluble recombinant B18R protects cultured cells from IFN and allows vaccinia virus replication.