MSE PRO™ tert-Butyl 7-oxo-2,6-diazaspiro[3.4]octane-2-carboxylate, ≥98.0% Purity

MSE PRO™ tert-Butyl 7-oxo-2,6-diazaspiro[3.4]octane-2-carboxylate is a versatile and valuable synthetic intermediate for organic synthesis. As a spirocyclic compound, it possesses a unique rigid bicyclic structure with a fused diazaspiro ring system. This structural motif is prevalent in many bioactive molecules and drug candidates, making it an attractive building block for medicinal chemistry applications. The presence of the tert-butyl carbamate protecting group allows for selective deprotection under mild acidic conditions, revealing a reactive amine functionality for further derivatization. This feature enables the controlled introduction of diverse substituents, facilitating the synthesis of complex heterocyclic scaffolds with potential biological activities.

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Technical Specifications:

CAS No.	1234616-51-3
Chemical name	tert-Butyl 7-oxo-2,6-diazaspiro[3.4]octane-2-carboxylate
Synonym(s)	tert-butyl-6-oxo-2,7-diazaspiro[3.4]octane-2-carboxylate 2,6-Diazaspiro[3.4]octane-2-carboxylic acid, 7-oxo-, 1,1-dimethylethyl ester
Molecular formula	C₁₁H₁₈N₂O₃
Pack size	5 g (CM1399); 25 g (CM1400)
Molecular weight	226.27 g/mol
Purity	98.22% (LCMS)
Boiling point	399.1±42.0 °C (Predicted)
Density	1.20±0.1 g/cm³
pKa	16.10±0.20 (Predicted)
Appearance	White to off-white solid
Storage	Store at room temperature

References:

[1] Fu, K., Xu, W., Yang, R., Zhao, H., Xu, H., Wei, Y., ... & Xiong, B. (2023). 2, 6-diazaspiro [3.4] octan-7-one derivatives as potent sigma-1 receptor antagonists that enhanced the antinociceptive effect of morphine and rescued morphine tolerance. European Journal of Medicinal Chemistry, 249, 115178.

[2] Martínez-Viturro, C. M., Trabanco, A. A., Royes, J., Fernández, E., Tresadern, G., Vega, J. A., ... & Bartolomé-Nebreda, J. M. (2020). Diazaspirononane nonsaccharide inhibitors of O-GlcNAcase (OGA) for the treatment of neurodegenerative disorders. Journal of medicinal chemistry, 63(22), 14017-14044.

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