MSE PRO 3,3-Difluoropyrrolidine hydrochloride, ≥97.0% Purity

MSE PRO™ 3,3-Difluoropyrrolidine hydrochloride, ≥97.0% Purity

MSE PRO™ 3,3-Difluoropyrrolidine hydrochloride is a pyrrolidine salt containing fluorine, with the amine group protonated by hydrochloric acid, imparting unique structural and property characteristics. The presence of two fluorine atoms on the pyrrolidine ring makes this compound a valuable building block for the synthesis of fluorinated heterocycles and pharmaceutically active compounds, as fluorination can modulate the physicochemical and biological properties of drug candidates.

MSE Supplies offers various N-heterocyclic drug small molecules and other chemical reagents. Please contact us for bulk orders.

Technical Specifications:

References:

[1] Caldwell, C. G., Chen, P., He, J., Parmee, E. R., Leiting, B., Marsilio, F., ... & Weber, A. E. (2004). Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors. Bioorganic & medicinal chemistry letters, 14(5), 1265-1268.

[2] Wei, L., Makowski, T. M., & Rutherford, J. L. (2012). An efficient synthesis of 3, 3-difluoro-pyrrolidine hydrochloride starting with 2-chloro-2, 2-difluoroacetic acid. Journal of Fluorine Chemistry, 135, 354-357.