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MSE PRO Clostripain (Endoproteinase-Arg-C) Sequencing Grade
SKU: BO0079
MSE PRO™ Clostripain (Endoproteinase-Arg-C) Sequencing Grade
The MSE PRO™ Clostridial protease is a collagenase-related double-stranded protease isolated from Clostridium histolyticum. It has highly restricted substrate specificity for the Arg-Xaa peptide bond. Therefore, Clostridium protease has been explored as a potential protein sequencing enzyme. It has also been investigated as a catalyst for the condensation of pharmacologically important peptides containing Arg-Pro bonds. Activation is dependent on dithiothreitol, cysteine, or other sulfhydryl-containing reagents. The enzyme can be inhibited by oxidizing agents and sulfhydryl reactants as well as Co2+, Cu2+, Cd2+ and heavy metal ion
Brand: MSE PRO™
Manufacturer: MSE Supplies LLC
MSE Supplies offers a variety of Biochemical Reagents. Please contact us for SDS, lead time and more information.
Applications:
Can be used as a catalyst for the condensation of important drug peptides containing Arg-Pro peptide bonds. Used as a protein hydrolase in perfusate to test its effect on hematocrit in tubes. Also used for restriction disassembly of T4 phage DNA polymerase.
Specifications:
| SKU# | BO0079 |
| EC No. | 3.4.22.8 |
| Biological Source | Clostridium histolyticum |
| Activity | ≥50 U/mg dw |
| Unit Definition | One unit hydrolyzes 1 μmol of ethyl N-benzoyl-L-arginate per minute at 25°C, pH 7.6 in the presence of dithiothreitol. |
| Storage | 2-8°C |
| Note | Product packaging is subject to change, the picture is for reference only. |