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Recombinant Human 4-1BB/TNFRSF9 Protein (Fc Tag)(Active)
SKU: PKSH032026-50
Recombinant Human 4-1BB/TNFRSF9 Protein (Fc Tag)(Active)
| SKU # | PKSH032026 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | 4-1BB ligand receptor, CD137, CDw137, ILA, T-cell antigen 4-1BB homolog, T-cell antigen ILA, TNFRSF9 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Leu24-Gln186 |
| Accession | Q07011 |
| Calculated Molecular Weight | 44.2 kDa |
| Observed Molecular Weight | 58 kDa |
| Tag | C-Fc |
| Bio-activity | Immobilized Human 4-1BBL-His(Cat: PKSH032023) at 10 μg/ml(100 μl/well) can bind Human 4-1BB-Fc. The ED50 of Human 4-1BB-Fc is 16. 8 ng/ml. |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Tumor necrosis factor receptor superfamily member 9(TNFRSF9); also known as CD137 and 4-1BB; is an inducible T cell surface protein belonging to the tumor necrosis factor receptor superfamily. It is a single-pass type I membrane protein which contains 4 TNFR-Cys repeats. The human and mouse proteins share 60% amino acid sequence identity. CD137 is expressed by mesenchymal cells; including endothelial cells; chondrocytes; and cells of the central nervous system. CD137 is also broadly expressed by cells of the human immune system; is broadly expressed by cells of the human immune system; including activated CD8+ and CD4+ T cells; activated natural killer (NK) cells; follicular dendritic cells (FDCs) and monocytes. CD137 has diverse roles in the immune response; the one key function is to promote the survival of both T cells and dendritic cells by binding the cognate ligand CD137L (4-1BBL).