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Recombinant Human ACADM/MCAD Protein (His Tag)
SKU: PKSH032032-50
Recombinant Human ACADM/MCAD Protein (His Tag)
| SKU # | PKSH032032 |
| Expression Host | E.coli |
Description
| Synonyms | ACADM, MCAD, Medium-Chain Specific Acyl-CoA Dehydrogenase Mitochondrial |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Lys26-Asn421 |
| Accession | P11310 |
| Calculated Molecular Weight | 45.9 kDa |
| Observed Molecular Weight | 42 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Acetate, 10% Trehalose, 0.05% Tween 80, pH 5.0. |
| Reconstitution | Not Applicable |
Background
Medium-Chain Specific Acyl-CoA Dehydrogenase (ACADM) is a mitochondrial fatty acid beta-oxidation that belongs to the acyl-CoA dehydrogenase family. ACADM is a homotetramer enzyme that catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. ACADM is specific for acyl chain lengths of 4 to 16. It is essential for converting these particular fatty acids to energy, especially during fasting periods. Defects in ACADM cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death.