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Recombinant Human Activin RIIA/ACVR2A Protein (Fc & His Tag)(Active)
SKU: PKSH032039-50
Recombinant Human Activin RIIA/ACVR2A Protein (Fc & His Tag)(Active)
| SKU # | PKSH032039 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | ACTR-IIA, ACTRIIA, ACVR2, ACVR2A, Activin Receptor Type IIA, Activin Receptor Type-2A |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ala20-Pro134 |
| Accession | P27037 |
| Calculated Molecular Weight | 41.2 kDa |
| Observed Molecular Weight | 60kDa&40kDa |
| Tag | C-Fc-His |
| Bio-activity | Immobilized Human INHBC-His at 10μg/ml (100 μl/well) can bind Human ACVR2A-Fc-His. The ED50 of Recombinant Human ACVR2A-Fc-His is 2-8 ug/ml. |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins; composed of a ligand-binding extracellular domain with cysteine-rich region; a transmembrane domain; and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding; resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.