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Recombinant Human ALK-2/ACVR1 Protein (Human Cells, His Tag)
SKU: PKSH032036-50
Recombinant Human ALK-2/ACVR1 Protein (Human Cells, His Tag)
| SKU # | PKSH032036 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | ACTR-I, ACVR1, ACVR1A, ACVRLK2, ALK-2, ALK2, Activin Receptor Type I, Activin Receptor Type-1, Activin Receptor-Like Kinase 2, FOP, SKR1, Serine/Threonine-Protein Kinase Receptor R1, TGF-B Superfamily Receptor Type I, TSR-I |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met21-Val124 |
| Accession | Q04771 |
| Calculated Molecular Weight | 12.6 kDa |
| Observed Molecular Weight | 17 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Activin receptor type-1; also known as Activin receptor type I; Activin receptor-like kinase 2; Serine/threonine-protein kinase receptor R1; TGF-B superfamily receptor type I; ACVRLK2 and ACVR1; is a single-pass type I membrane protein. ACVR1 is expressed in normal parenchymal cells; endothelial cells; fibroblasts and tumor-derived epithelial cells. ACVR1 belongs to the protein kinase superfamily. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins; composed of a ligand-binding extracellular domain with cysteine-rich region; a transmembrane domain; and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding; resulting in phosphorylation of type I receptors by type II receptors. ACVR1 signals a particular transcriptional response in concert with activin type II receptors.