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Recombinant Human Calumenin Protein (aa 1-311, His Tag)
SKU: PKSH030624-100
Recombinant Human Calumenin Protein (aa 1-311, His Tag)
| SKU # | PKSH030624 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CALU, Calumenin, Crocalbin, IEF SSP 9302 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Arg311 |
| Accession | O43852-1 |
| Calculated Molecular Weight | 35.9 kDa |
| Observed Molecular Weight | 46-52 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Calumenin belongs to the CREC family. It contains 6 EF-hand domains. Calumenin is expressed in skeletal muscle (at protein level). Calumenin interacts with GGCX and RYR1 in the presence of calcium ions; but not in the presence of EDTA. Calumenin is Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. It seems to inhibit gamma-carboxylase GGCX. Calumenin also binds 7 calcium ions with a low affinity and may modulate calcium release from the sarcoplasmic reticulum.