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Recombinant Human Cathepsin S/CTSS Protein (His Tag)(Active)
SKU: PKSH033736-50
Recombinant Human Cathepsin S/CTSS Protein (His Tag)(Active)
| SKU # | PKSH033736 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CTSS, Cathepsin S, MGC3886 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gln17-Ile331 |
| Accession | AAH02642.1 |
| Calculated Molecular Weight | 36.9&25&11.2 kDa |
| Observed Molecular Weight | 37-40&26-28&14-16 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, 10% Glycerol, pH 5.5. |
| Reconstitution | Not Applicable |
Background
Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. This protein is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia. Moreover, cathepsin S is expressed in some epithelial cells. Compared with the abundant cathepsins B, LandH, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicated that cathepsin S generates A beta from amyloidogenic fragments of beta APP in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease(AD) and Down Syndrome (DS).