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Recombinant Human CRADD/RAIDD Protein
SKU: PKSH033738-50
Recombinant Human CRADD/RAIDD Protein
| SKU # | PKSH033738 |
| Expression Host | E.coli |
Description
| Synonyms | CRADD, Caspase and RIP Adapter with Death Domain, Death Domain-Containing Protein CRADD, RAIDD, RIP-Associated Protein with A Death Domain |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met1-Glu199 |
| Accession | P78560 |
| Calculated Molecular Weight | 23 kDa |
| Observed Molecular Weight | 21 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Death Domain-Containing Protein CRADD (CRADD) is widely expressed in most tissues; with particularly high expression in the adult heart; testis; liver; skeletal muscle; fetal liver; and kidney. CRADD contains one CARD domain that mediates the interaction with caspase-2; and one death domain involved in the binding of RIP protein. CRADD functions as an apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. CRADD induces cell apoptosis/cell death in numerous tissues. Defects in CRADD will result in mental retardation.