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Recombinant Human Eotaxin-3/CCL26 Protein (aa 24-94)
SKU: PKSH033733-50
Recombinant Human Eotaxin-3/CCL26 Protein (aa 24-94)
| SKU # | PKSH033733 |
| Expression Host | E.coli |
Description
| Synonyms | C-C Motif Chemokine 26, CC Chemokine IMAC, CCL26, Eotaxin-3, MIP-4-Alpha, Macrophage Inflammatory Protein 4-Alpha, SCYA26, Small-Inducible Cytokine A26, TSC-1, Thymic Stroma Chemokine-1 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Thr24-Leu94 |
| Accession | Q9Y258 |
| Calculated Molecular Weight | 8.5 kDa |
| Observed Molecular Weight | 13 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 1mM EDTA, 20% Glycerol, pH 9.0. |
| Reconstitution | Not Applicable |
Background
Chemokine Ligand 26 protein (CCL26) is a novel small cytokine belonging to the CC chemokine family which is involved in immunoregulatory and inflammatory processes. CCL26 is constitutively expressed in thymus; but only transiently expressed in phytohemagglutinin-stimulated peripheral blood mononuclear cells. It specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. CCL26; along with Eotaxin-1 and Eotaxin-2; selectively activates the CC chemokine receptor 3 (CCR3). The Eotaxin-3-CCR3 interaction may play an important role in allergic diseases such as atopic dermatitis and bronchial asthma. The full-length cDNA for CCL26 encodes a protein of 94 amino acids with a putative signal peptide of either 23 or 26 amino acid residues. Both the 71 and 68 amino acid residue variants of recombinant CCL26 demonstrate equal potency in inducing chemotaxis of a human CCR3-transfected cell line. Unlike most other CC chemokines; CCL26 maps to human chromosome 7q11.2; within 40 kilobases of the Eotaxin-2 loci. CCL26 and Eotaxin-2 are unique in that they are the only chemokines identified to date that map to chromosome 7.