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Recombinant Human Jumping Translocation Breakpoint/JTB Protein (Fc Tag)
SKU: PKSH030629-100
Recombinant Human Jumping Translocation Breakpoint/JTB Protein (Fc Tag)
| SKU # | PKSH030629 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | HJTB, HSPC222, JTB, PAR, hJT |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Leu105 |
| Accession | O76095-1 |
| Calculated Molecular Weight | 34.7 kDa |
| Observed Molecular Weight | 38 kDa |
| Tag | C-mFc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 85 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Jumping translocation breakpoint, also known as JTB, is a member of the JTB family. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomalsegments jumping to various telomeres. JTB is expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. It is required for normal cytokinesis during mitosis. JTB plays a role in the regulation of cell proliferation. It may be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly.