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Recombinant Human MTHFS Protein (His Tag)
SKU: PKSH032029-50
Recombinant Human MTHFS Protein (His Tag)
| SKU # | PKSH032029 |
| Expression Host | E.coli |
Description
| Synonyms | 5,10-methenyl-tetrahydrofolate synthetase, 5-formyltetrahydrofolate cyclo-ligase, MTHFS, Methenyl-THF synthetase |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Ala203 |
| Accession | P49914 |
| Calculated Molecular Weight | 24.3 kDa |
| Observed Molecular Weight | 28 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM Nacl, 1mM DTT, 50% Glycerol, pH 8.0. |
| Reconstitution | Not Applicable |
Background
5-formyltetrahydrofolate cyclo-ligase (MTHFS) belongs to the 5-formyltetrahydrofolate cyclo-ligase family. It is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, contributes to tetrahydrofolate metabolism. MTHFS helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion.