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Recombinant Human UBE2D1 Protein (GST Tag)– MSE Supplies LLC
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Recombinant Human UBE2D1 Protein (GST Tag)

SKU: PKSH033367-50

  • £9700
  • Save £1200



Recombinant Human UBE2D1 Protein (GST Tag)

 

SKU # PKSH033367
Expression Host E.coli

 

 

Description

Synonyms SFT, Stimulator of Fe transport, UBC4/5 homolog, UBC5A, UBCH5, UBCH5A, UbcH5, Ubiquitin carrier protein D1, Ubiquitin-conjugating enzyme E2 D1, Ubiquitin-conjugating enzyme E2(17)KB 1, Ubiquitin-conjugating enzyme E2-17 kDa 1, Ubiquitin-protein ligase D1
Species Human
Expression Host E.coli
Sequence Met 1-Met 147
Accession P51668
Calculated Molecular Weight 42.9 kDa
Observed Molecular Weight 40 kDa
Tag N-GST
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 2mM DTT, 10% Glycerol, pH 7.5.
Reconstitution Not Applicable



Background

Ubiquitin-conjugating enzyme E2 D1(UBE2D1)belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes; or E1s; ubiquitin-conjugating enzymes; or E2s; and ubiquitin-protein ligases; or E3s. This enzyme is closely related to a stimulator of iron transport (SFT); and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.