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Recombinant Human Activin Receptor 2B/ACVR2B Protein (His Tag)
SKU: PKSH032040-50
Recombinant Human Activin Receptor 2B/ACVR2B Protein (His Tag)
| SKU # | PKSH032040 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | ACTR-IIB, ACVR2B, Activin Receptor Type IIB, Activin Receptor Type-2B, BMP Type II Receptor, BMP Type-2 Receptor, BMPR-2, Bone Morphogenetic Protein Receptor Type II, Bone Morphogenetic Protein Receptor Type-2 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ser19-Thr134 |
| Accession | Q13705 |
| Calculated Molecular Weight | 14.4 kDa |
| Observed Molecular Weight | 25-38 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily; exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding; type I and II receptors form a stable complex; resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity; and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB; also known as ActRIIB; is a type II receptor containing an extracellular domain (ECD); a transmembrane segment; and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A; activin B and inhibin A. Multiple ActRIIB isoforms can also be generated; which bind activin isoforms with different affinities.